diff --git a/src/cthulhu/plugins/PluginManager/plugin.py b/src/cthulhu/plugins/PluginManager/plugin.py
index f336471..cb913cd 100644
--- a/src/cthulhu/plugins/PluginManager/plugin.py
+++ b/src/cthulhu/plugins/PluginManager/plugin.py
@@ -458,19 +458,34 @@ class PluginManager(Plugin):
                 active_plugins.remove(plugin_name)
 
             _settingsManager.setSetting('activePlugins', active_plugins)
+            if hasattr(_settingsManager, "general") and isinstance(_settingsManager.general, dict):
+                _settingsManager.general['activePlugins'] = active_plugins
 
             try:
-                current_general = _settingsManager.getGeneralSettings()
+                active_profile = _settingsManager.getSetting('activeProfile')
+                if isinstance(active_profile, (list, tuple)) and len(active_profile) > 1:
+                    profile_name = active_profile[1]
+                else:
+                    profile_name = _settingsManager.profile or 'default'
+
+                current_general = _settingsManager.getGeneralSettings(profile_name) or {}
                 current_general['activePlugins'] = active_plugins
 
+                _settingsManager.profile = profile_name
+                _settingsManager._setProfileGeneral(current_general)
+
+                pronunciations = _settingsManager.getPronunciations(profile_name) or {}
+                keybindings = _settingsManager.getKeybindings(profile_name) or {}
+
                 backend = _settingsManager._backend
                 if backend:
-                    backend.saveDefaultSettings(
-                        current_general,
-                        _settingsManager.getPronunciations(),
-                        _settingsManager.getKeybindings()
+                    backend.saveProfileSettings(
+                        profile_name,
+                        _settingsManager.profileGeneral,
+                        pronunciations,
+                        keybindings
                     )
-                    debug.printMessage(debug.LEVEL_INFO, "PluginManager: Settings saved to backend", True)
+                    debug.printMessage(debug.LEVEL_INFO, f"PluginManager: Settings saved to backend (profile {profile_name})", True)
                 else:
                     debug.printMessage(debug.LEVEL_INFO, "PluginManager: No backend available for saving", True)